本刊推荐：研究人员针对急性早幼粒细胞白血病(APL)中罕见变异型融合基因开展研究，报道一例仅携带单PML::RARA融合（位于der(17)）而无典型RARA::PML reciprocal融合的APL病例。通过细胞遗传学与分子检测技术，证实该患者对全反式维甲酸(ATRA)联合三氧化二砷(ATO)疗法 ...

Retinoic acid and arsenic trioxide target the protein stability and transcriptional repression activity of the fusion oncoprotein PML-RARA, resulting in regression of acute promyelocytic leukemia (APL ...

ALDH1A3通过协同转录因子MAZ抑制PML-RARA表达，其调控机制涉及DNA甲基化，临床去甲基化治疗可显著改善复发APL患者预后。 作者：焦彩、梁成辉、韩丽萍、江红英、段江杰、李富、刘佳、梁彩、高雷、余世仓 单位：中国陆军军医大学第一附属医院（西南医院）病理 ...

Acute promyelocytic leukemia (APL) represents about 10% of acute myeloid leukemias and is characterized by a specific translocation between chromosomes 15 and 17, resulting in the fusion of the ...