Top: Hematoxylin and eosin (HE) staining of the epipharyngeal mucosa. Bottom: Clustered gene expression map obtained from the same tissue section using Visium HD spatial transcriptomics. Credit must ...

Spatial transcriptomics (ST) technologies reveal the spatial organization of gene expression in tissues, providing critical insights into development, neurobiology, and cancer. However, the high cost ...

In the brain, location is everything. And the throngs of cells that live there are nothing without the billions of distinct connections between them. Although scientists can use single-cell ...

In a recent study published in Nature Communications, a team of researchers at the Carl R. Woese Institute for Genomic Biology reports a new, robust computational toolset to extract biological ...

We combine advanced technologies such as spatial transcriptomics, multiplexed imaging, and in situ sequencing to map cellular components in their native tissue context. Obtain high-resolution data ...

Applying single-cell RNA sequencing has led researchers to be able to profile the entire transcriptome of cells. However, these transcriptomes prove difficult to link back to their original location ...

A series of announcements in recent weeks shows just how much the spatial biology field has matured in the years since Nature Methods recognized spatial biology—which it called spatially resolved ...

Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located. However, the rapid growth of the technology has come at the cost of ...

Technological development is key to improving the way hematologic cancer is diagnosed and treated. With this vision, the Josep Carreras Leukemia Research Institute is committed to the creation and ...

A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the ...